张园娇(邮箱:zyj494@njucm.edu.cn),博士,副教授,硕士生导师,现任南京中医药大学医学院专任教师,南京中医药大学校C类特聘引进人才。
主要从事多发性骨髓瘤的靶点发现与干预研究。主持国家自然科学基金青年项目1项、南京中医药大学特聘教授配套项目1项,参与1项国家重点研发计划课题和多项国家自然科学基金面上项目。以第一及共同一作身份在Signal Transduction and Targeted Therapy、Clinical and Translational Medicine、Cancer communications等国际知名期刊发表SCI论文数篇,单篇最高影响因子为39.3;指导本科生获得全国大学生基础医学创新研究大赛三等奖。
代表性研究论文
1.Yuanjiao Zhang; Jinjun Qian; Chunyan Gu#; Ye Yang#. Alternative splicing and cancer: a systematic review, Signal Transduction and Targeted Therapy, 2021, 6:78. (医学一区,IF:39.3)
2.Yuanjiao Zhang; Xichao Yu; Rongze Sun; Jie Min; Xiaozhu Tang; Zigen Lin; Siyuan Xie; Xinying Li; Shengfeng Lu; Zhidan Tian; Chunyan Gu#; Lesheng Teng#; Ye Yang#. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication, Clinical and Translational Medicine, 2022;12(2):e684.(医学一区,IF:10.6)
3.Rongfang Wei; Yan Zhu; Yuanjiao Zhang (co-first author); Wene Zhao; Xichao Yu; Ling Wang; Chunyan Gu#, Xiaosong Gu#, Ye Yang#. AIMP1 promotes multiple myeloma malignancy through interacting with ANP32A to mediate histone H3 acetylation, Cancer Communications, 2022, 1:22. (医学一区,IF:15.283)
4.Yuanjiao Zhang; Zhendong Deng; Shanliang Sun; Siyuan Xie; Mingmei Jiang; Bing Chen#; Chunyan Gu#; Ye Yang#. NAT10 acetylates BCL-XL mRNA to promote the proliferation of multiple myeloma cells through PI3K-AKT pathway, Frontiers in oncology, 2022;12:967811.(医学二区,IF:4.7)
5.Yuanjiao Zhang; Jiacheng Qian; Mingmei Jiang; Shu Yang; Lianxin Zhou; Qin Zhang#; Liping Lin#; Ye Yang#. LTe2 induces cell apoptosis in multiple myeloma by suppressing AKT phosphorylation at Thr308 and Ser473. Frontiers in oncology, 2023;13:1269670.(医学二区,IF:4.7)